Shao H Yang Selected Research

p21(ras) farnesyl-protein transferase (protein farnesyltransferase)

2/2013	Targeting protein prenylation in progeria.
4/2010	Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer.
2/2010	Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria.
10/2006	Protein farnesyltransferase inhibitors and progeria.
3/2006	A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.
7/2005	Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

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Shao H Yang Research Topics

Disease

21	Progeria (Hutchinson Gilford Syndrome) 04/2016 - 12/2004
2	Inborn Genetic Diseases (Disease, Hereditary) 05/2015 - 09/2011
2	Cardiomyopathies (Cardiomyopathy) 02/2013 - 01/2011
2	Carcinogenesis 04/2010 - 01/2008
1	Esophageal Achalasia (Megaesophagus) 05/2015
1	Ichthyosis (Xeroderma) 12/2014
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2014
1	Lipodystrophy 02/2013
1	Demyelinating Diseases (Demyelinating Disease) 02/2013
1	Muscular Dystrophies (Muscular Dystrophy) 02/2013
1	Peripheral Nervous System Diseases (PNS Diseases) 02/2013
1	Leukoencephalopathies 02/2013
1	Hyperbilirubinemia 01/2012
1	Blister (Bulla) 07/2010
1	Neoplasm Metastasis (Metastasis) 04/2010
1	Lung Neoplasms (Lung Cancer) 04/2010
1	Neoplasms (Cancer) 04/2010
1	Premature Aging 10/2008
1	Rare Diseases (Rare Disease) 10/2008
1	Muscle Weakness 03/2006
1	Osteoporosis 12/2004
1	Alopecia (Baldness) 12/2004
1	Micrognathism 12/2004

Drug/Important Bio-Agent (IBA)

20	prelamin AIBA 04/2016 - 12/2004
7	Lamin Type A (Lamin A)IBA 01/2011 - 12/2004
6	p21(ras) farnesyl-protein transferase (protein farnesyltransferase)IBA 02/2013 - 07/2005
5	lamin CIBA 04/2016 - 07/2005
3	LaminsIBA 12/2014 - 09/2011
2	geranylgeranyltransferase type-I (protein geranylgeranyltransferase)IBA 01/2012 - 04/2010
2	Proteins (Proteins, Gene)FDA Link 04/2010 - 01/2008
2	LipidsIBA 04/2010 - 01/2009
2	Farnesyltranstransferase (Farnesyltransferase)IBA 01/2008 - 08/2006
1	ChromatinIBA 12/2014
1	lonafarnib (SCH 66336)IBA 02/2013
1	Lamin Type B (Lamin B)IBA 02/2013
1	Transaminases (Aminotransferases)IBA 01/2012
1	RNA Splice SitesIBA 07/2009
1	Antisense OligonucleotidesIBA 07/2009
1	Protein Isoforms (Isoforms)IBA 01/2008
1	glycylpeptide N-tetradecanoyltransferaseIBA 01/2008
1	EnzymesIBA 03/2006

Therapy/Procedure

1	Therapeutics 04/2010